Indications for collagenase clostridium histolyticum in the treatment of Dupuytren’s disease must be defined

The launch of collagenase clostridium histolyticum for the treatment of Dupuytren’s disease almost 10 years ago not only represented a completely new treatment approach for this difficult and still unsolved hand surgical problem, but also triggered a huge wave of related research. Surgeons were confronted with an effective non-surgical treatment that could change completely the approach to this disease.

Like many other surgical and medical treatments, collagenase clostridium histolyticum (CCH) also went through the well-known Rogers’ curve of innovation adoption. After early enthusiasm, some limitations and problems became evident. In particular, some aspects like recurrence vs. extension, recurrence rate, complication rate and cost-effectiveness were better analyzed and newly defined. These studies also contributed to and improved the level of evidence unlike the older papers in this area.

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